[HTML][HTML] Two-year cortical trajectories are abnormal in children and adolescents with prenatal alcohol exposure
Developmental cognitive neuroscience, 2018•Elsevier
Objectives Cortical abnormalities in prenatal alcohol exposure (PAE) are known, including
in gyrification (LGI), thickness (CT), volume (CV), and surface area (CS). This study provides
longitudinal and developmental context to the PAE cortical development literature.
Experimental design Included: 58 children with PAE and 52 controls, ages 6–17 at
enrollment, from four Collaborative Initiative on FASD (CIFASD) sites. Participants
underwent a formal evaluation of physical anomalies and dysmorphic facial features …
in gyrification (LGI), thickness (CT), volume (CV), and surface area (CS). This study provides
longitudinal and developmental context to the PAE cortical development literature.
Experimental design Included: 58 children with PAE and 52 controls, ages 6–17 at
enrollment, from four Collaborative Initiative on FASD (CIFASD) sites. Participants
underwent a formal evaluation of physical anomalies and dysmorphic facial features …
Objectives
Cortical abnormalities in prenatal alcohol exposure (PAE) are known, including in gyrification (LGI), thickness (CT), volume (CV), and surface area (CS). This study provides longitudinal and developmental context to the PAE cortical development literature.
Experimental design
Included: 58 children with PAE and 52 controls, ages 6–17 at enrollment, from four Collaborative Initiative on FASD (CIFASD) sites. Participants underwent a formal evaluation of physical anomalies and dysmorphic facial features associated with PAE. MRI data were collected on three platforms (Siemens, GE, and Philips) at four sites. Scans were spaced two years apart. Change in LGI, CT, CS, and CV were examined.
Principal observations
Several significant regional age-by-diagnosis linear and quadratic interaction effects in LGI, CT, and CV were found, indicating atypical developmental trajectories in PAE. No significant correlations were observed between cortical measures and IQ.
Conclusions
Regional differences were seen longitudinally in CT, CV, and LGI in those with PAE. The findings represent important insights into developmental trajectories and may have implications for the timing of assessments and interventions in this population. It is noteworthy that cortical metrics did not correlate with IQ, suggesting that more specific aspects of cognitive development may need to be explored to provide further context.
Elsevier
以上显示的是最相近的搜索结果。 查看全部搜索结果