… , ubiquitin can also be acetylated on Lys, or phosphorylated on Ser, Thr or Tyr residues, and
each modification … While the number of distinctly modified ubiquitin species in cells is mind-…

… modification by the small, highly conserved ubiquitin polypeptide, a number of distinct
ubiquitin-… A growing body of data also implicates the dysregulation of Ubl-substrate modification …

… modifications (PTMs) and regulates numerous cellular functions. Interestingly, ubiquitin (Ub)
can be itself modified … S65 being the most frequently modified in yeast and mammalian cells, …

… -section of the proteome is subject to ubiquitin modification at some point during its lifetime.
… that are modified by the ubiquitin system as well as the actual site of modification—requires a …

… ubiquitin chains provides greater diversity in signaling potential… Ubiquitin modifications are
assembled by a hierarchical cascade comprising ubiquitin-activating enzymes (E1), ubiquitin…

… in tandem as tools to investigate ubiquitin-modified proteomes. Specifically, we focus on the
… poly)ubiquitin-modified proteins and more broadly for the targeted manipulation of ubiquitin-…

… Here, the substrate is modified with the 76 amino acid peptide, ubiquitin. Ubiquitin modification
… integral membrane proteins are also modified with ubiquitin. After or concordant with the …

… Ubiquitin modification of target lysine residues typically marks substrates for proteasome-…
ubiquitin ligase targets. Here we provide a detailed method to interrogate the ubiquitin-modified …

Covalent attachment of ubiquitin-like proteins (Ubls) is a predominant mechanism for regulating
protein function in eukaryotes. Several structurally related Ubls, such as ubiquitin, SUMO…

… The ubiquitination machinery is capable of appending a variety of ubiquitin modifications
to substrates. The attachment of a single ubiquitin polypeptide, monoubiquitin, to a substrate …