… ubiquitin pathway. In this review, we focus on how ubiquitin signaling guides the fate and
function of Rho GTPases and their regulators, especially how the E3 ubiquitin ligase Smurf1 …

… which, upon association with E2 enzymes carrying ubiquitin, initiates a thioester bond with
the ubiquitin C terminus. This facilitates the subsequent transfer of ubiquitin to a substrate (S). …

… Citation53 Since constitutive ubiquitination would be detrimental to the cell, these studies …
that would remove ubiquitin from these proteins blocking downstream signaling responses and …

… The Rho family of small GTPases plays a key role in the … We found that Smurf1, a HECT
domain E3 ubiquitin ligase, could … of Smurf1‐regulated RhoA ubiquitination and degradation. …

… that ubiquitination is involved in regulation of Rho GTPases’ … In this review, we will discuss
the effects of ubiquitination and … interacting proteins, and small Rho GTPases. We provide an …

… In addition, Cdc42-mediated recruitment of the E3 ubiquitin ligase Smurf1 to cellular … RhoA
signaling during dynamic membrane movements. These data suggest that regulation of Rho …

… In this review we will discuss how, in turn, the cell cycle machinery influences Rho
signaling … level and by ubiquitin-dependent degradation. In this respect, such proteins of the …

… in RHO proteins. In animals, both phosphorylation and ubiquitination are employed to control
RHO signaling… The mammalian RHO family member Rac1 for instance is phosphorylated at …

… ) FBXL19 E3 ubiquitin ligase targets Rac1, a related member of the Rho family for … signaling
biomolecules by modulating their activity, localization, and protein stability. Ubiquitination of …

… hypothesize that the E3 ubiquitin ligase, Smurf1, … for ubiquitination and degradation via
Smurf1. Together our data suggest that localized regulation of Rho GTPases by specific signaling …