Advances in robotics, surgical instrumentation, and real-time imaging inside the body have made it possible to switch various surgeries to minimally invasive ones. However, for many surgical procedures that require reconnecting tissue or attaching prosthetic materials, a minimally invasive way to perform them does not yet exist. Stapling and suturing are harsh techniques that can cause local tissue damage from deep piercing. In some cases, their removal after wound healing can also inflict damage. Tissue adhesives could potentially reduce the harm of surgical procedures, decrease operative times, and improve the surgical outcomes. Although promising approaches have been developed, tissue adhesives for wound closure are now mainly used in combination with sutures and staples. On page 751 of this issue, Ma et al. introduce an ultrasound-mediated approach to enhance the adhesive performance of soft hydrogels on various tissues.