Ultrahigh resolution and full-length pilin structures with insights for filament assembly, pathogenic functions, and vaccine potential
S Hartung, AS Arvai, T Wood, S Kolappan… - Journal of Biological …, 2011 - ASBMB
Pilin proteins assemble into Type IV pili (T4P), surface-displayed bacterial filaments with
virulence functions including motility, attachment, transformation, immune escape, and
colony formation. However, challenges in crystallizing full-length fiber-forming and
membrane protein pilins leave unanswered questions regarding pilin structures, assembly,
functions, and vaccine potential. Here we report pilin structures of full-length DnFimA from
the sheep pathogen Dichelobacter nodosus and FtPilE from the human pathogen …
virulence functions including motility, attachment, transformation, immune escape, and
colony formation. However, challenges in crystallizing full-length fiber-forming and
membrane protein pilins leave unanswered questions regarding pilin structures, assembly,
functions, and vaccine potential. Here we report pilin structures of full-length DnFimA from
the sheep pathogen Dichelobacter nodosus and FtPilE from the human pathogen …
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