In the past two decades, optical coherence tomography (OCT) has been established as an
adjunct diagnostic technique for noninvasive, high-resolution, cross-sectional imaging in a
variety of medical fields. The rapid development of ultrabroad bandwidth light sources has
recently enabled a significant improvement in OCT imaging resolution, demonstrating the
potential of OCT to accomplish its original goal of performing noninvasive optical biopsies,
ie, the in vivo visualization of microstructural morphology in situ, which had previously only …

Ultrahigh resolution optical coherence tomography imaging is performed with a compact
broadband superluminescent diode light source. The source consists of two multiplexed
broadband superluminescent diodes and has a power output of 4 mW with a spectral
bandwidth of 155 nm, centered at a wavelength of 890 nm. In vivo imaging was performed
with approximately 2.3 µm axial resolution in scattering tissue and approximately 3.2 µm
axial resolution in the retina. These results demonstrate that it is possible to perform in vivo …