Ultrasoundenhanced transdermal transport

G Merino, YN Kalia, RH Guy - Journal of pharmaceutical sciences, 2003 - Elsevier
enhancement of transdermal transport by ultrasound is reviewed. After a brief discussion of
the physics of ultrasound … low‐frequency ultrasound on the transport of substances across the …

Ultrasound and transdermal drug delivery

I Lavon, J Kost - Drug discovery today, 2004 - Elsevier
… Tachibana [41, 55] reported that the use of low-frequency ultrasound (48 kHz) enhanced
transdermal transport of insulin across diabetic rat skin. Merino et al. [18] compared the …

Recent advances in ultrasound-based transdermal drug delivery

BCQ Seah, BM Teo - International journal of nanomedicine, 2018 - Taylor & Francis
ultrasound to validate that the previously ascertained results were applicable to transdermal
transport. … that dual-frequency SP enhanced the percutaneous transport of glucose ( Figure …

A mechanistic study of ultrasonically‐enhanced transdermal drug delivery

S Mitragotri, DA Edwards, D Blankschtein… - Journal of …, 1995 - Elsevier
… However, we found that 1 MHz ultrasound enhanced estradiol transdermal transport by a
factor of 13, whereas 3 MHz ultrasound enhanced transport only by 50% (compare cases 1 …

Frequency and thermal effects on the enhancement of transdermal transport by sonophoresis

G Merino, YN Kalia, MB Delgado-Charro… - Journal of Controlled …, 2003 - Elsevier
… The aims of this work were: (i) to examine the role of ultrasound (US) frequency and
intensity on the transport of glucose and mannitol across porcine skin in vitro, (ii) to quantify the …

Ultrasound-enhanced transdermal delivery: recent advances and future challenges

MA Oberli, CM Schoellhammer, R Langer… - Therapeutic …, 2014 - Taylor & Francis
… the mechanisms of ultrasound-permeability enhancement, and … of ultrasound are discussed.
It is stressed that developing … for the purpose of visualizing the localized transport regions. …

Synergistic effects of chemical enhancers and therapeutic ultrasound on transdermal drug delivery

ME Johnson, S Mitragotri, A Patel… - Journal of …, 1996 - Elsevier
… chemical enhancers and ultrasound can each individually increase transdermal drug transport,
we … and ultrasound may result in a greater enhancement than that resulting from each …

Ultrasound mediated transdermal drug delivery

A Azagury, L Khoury, G Enden, J Kost - Advanced drug delivery reviews, 2014 - Elsevier
… The authors theorized that the enhanced transdermal transport in the course of low-frequency
ultrasound application occurs through the keratinocytes rather than the hair follicles. They …

Determination of threshold energy dose for ultrasound-induced transdermal drug transport

S Mitragotri, J Farrell, H Tang, T Terahara, J Kost… - Journal of controlled …, 2000 - Elsevier
… Hence we study the dependence of transdermal transport enhancement as well as
cavitation on ultrasound parameters including intensity, duty cycle and exposure time. …

An explanation for the variation of the sonophoretic transdermal transport enhancement from drug to drug

S Mitragotri, D Blankschtein… - Journal of …, 1997 - Wiley Online Library
… a transdermal delivery … enhancement from drug to drug. This paper also presents an equation
to qualitatively predict whether therapeutic ultrasound may enhance transdermal transport