In this study, hydrodynamic performance of Duisburg Test Case (DTC), a Post-Panamax container vessel, has been investigated by using Computational Fluid Dynamics (CFD) tools. Total resistance analyses have first been performed using an optimum grid number which has been determined by verification and validation processes based on Grid Convergence Index (GCI). Later, open water propeller analyses have been carried out by applying GCI for uncertainty approach. Finally, selfpropulsion analysis has been made for DTC hull by modelling the propeller using body force method for design speed. The major outcome of this study is to emphasize on the uncertainty assessment for calculating the ship’s total resistance and its open water propeller analyses. Additionally, the feasibility of body force method on self-propulsion performance prediction is discussed.