… The drug produced this unexpected effect at a dose 5× … oxaliplatin-induced mechanical
allodynia pain. The H 1 and H 4 … of Ca 2+ channel blockers and histamine receptor ligands, and …

… effect on cellular behaviour was evaluated through different in vitro assays. … through a
Matrigel®️layer and 4) reduces their movement from the edge of a simulated ‘wound’. Histamine …

… -a) mRNA expression via histamine H4 receptors contributes to … Unexpectedly, DL-76
significantly and in a dose-dependent … histamine functions are mediated by four histamine …

… interaction with four distinct histamine receptor subtypes (H1R… Ca2+ signalings through the
inositol trisphosphate receptor (… ders like Alzheimer’s and Parkinson’s disease is no surprise. …

… Moreover, the clinical activity of oxaliplatin administered into … LCK or chelation of intracellular
Ca2+ prevented the astemizole- … An unexpected link between immunogenic cell death and …

… B 2 , protease-activated receptor-2, histamine receptor H1 … so via nonselective potentiation
of protein kinase C and Ca 2+ … characterization of the surprising mechanosensitive properties …

… For example, oxaliplatin elicits mechanical and cold … Hence, it is not surprising that it
can also activate nociceptive … of pruritic sensors bare except for histamine H1 receptors (H1R). …

… In this context, it is perhaps not surprising that most … and PACAP and provokes the influx of
Ca 2+ and the activation of … of many drugs, including oxaliplatin and cisplatin. These cellular …

… (including NMDA/GluN receptors and K + /Ca 2+ channels), … That explains the surprising
result of free base crystallization … in hours or in days after oxaliplatin administration, which is …

… totally unpredictable); or a drug interaction with unexpected results… Typical effects of histamine
binding to H1 receptors include … Oxaliplatin was developed in an attempt to circumvent the …