Unliganded Thyroid Hormone Receptor α Regulates Developmental Timing via Gene Repression in Xenopus tropicalis
Thyroid hormone (TH) receptor (TR) expression begins early in development in all
vertebrates when circulating TH levels are absent or minimal, yet few developmental roles
for unliganded TRs have been established. Unliganded TRs are expected to repress TH-
response genes, increase tissue responsivity to TH, and regulate the timing of
developmental events. Here we examined the role of unliganded TRα in gene repression
and development in Xenopus tropicalis. We used transcription activator-like effector …
vertebrates when circulating TH levels are absent or minimal, yet few developmental roles
for unliganded TRs have been established. Unliganded TRs are expected to repress TH-
response genes, increase tissue responsivity to TH, and regulate the timing of
developmental events. Here we examined the role of unliganded TRα in gene repression
and development in Xenopus tropicalis. We used transcription activator-like effector …
[PDF][PDF] Unliganded Thyroid Hormone Receptor Regulates Developmental Timing via Gene Repression in Xenopus tropicalis
Thyroid hormone (TH) receptor (TR) expression begins early in development in all
vertebrates when circulating TH levels are absent or minimal, yet few developmental roles
for unliganded TRs have been established. Unliganded TRs are expected to repress TH-
response genes, increase tissue responsivity to TH, and regulate the timing of
developmental events. Here we examined the role of unliganded TRα in gene repression
and development in Xenopus tropicalis. We used transcription activator-like effector …
vertebrates when circulating TH levels are absent or minimal, yet few developmental roles
for unliganded TRs have been established. Unliganded TRs are expected to repress TH-
response genes, increase tissue responsivity to TH, and regulate the timing of
developmental events. Here we examined the role of unliganded TRα in gene repression
and development in Xenopus tropicalis. We used transcription activator-like effector …
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