Unsymmetrically disubstituted urea derivatives: A potent class of antiglycating agents
Bioorganic & medicinal chemistry, 2009•Elsevier
A series of unsymmetrically disubstituted urea derivatives 1–28 has been synthesized and
screened for their antiglycation activity in vitro. Compounds 26 (IC50= 4.26±0.25 μM), 1
(IC50= 5.8±0.08 μM), 22 (IC50= 4.26±0.25 μM), 6 (IC50= 6.4±0.02 μM), 5 (IC50= 6.6±0.26
μM), 2 (IC50= 7.02±0.31 μM), 3 (IC50= 7.14±0.84 μM), 27 (IC50= 7.27±0.36 μM), 4 (IC50=
8.16±1.04 μM), 21 (IC50= 8.4±0.15 μM), 23 (IC50= 9.0±0.35 μM) and 13 (IC50= 15.22±6.7
μM) showed an excellent antiglycation activity far better than the standard (rutin, IC50 …
screened for their antiglycation activity in vitro. Compounds 26 (IC50= 4.26±0.25 μM), 1
(IC50= 5.8±0.08 μM), 22 (IC50= 4.26±0.25 μM), 6 (IC50= 6.4±0.02 μM), 5 (IC50= 6.6±0.26
μM), 2 (IC50= 7.02±0.31 μM), 3 (IC50= 7.14±0.84 μM), 27 (IC50= 7.27±0.36 μM), 4 (IC50=
8.16±1.04 μM), 21 (IC50= 8.4±0.15 μM), 23 (IC50= 9.0±0.35 μM) and 13 (IC50= 15.22±6.7
μM) showed an excellent antiglycation activity far better than the standard (rutin, IC50 …
A series of unsymmetrically disubstituted urea derivatives 1–28 has been synthesized and screened for their antiglycation activity in vitro. Compounds 26 (IC50=4.26±0.25μM), 1 (IC50=5.8±0.08μM), 22 (IC50=4.26±0.25μM), 6 (IC50=6.4±0.02μM), 5 (IC50=6.6±0.26μM), 2 (IC50=7.02±0.31μM), 3 (IC50=7.14±0.84μM), 27 (IC50=7.27±0.36μM), 4 (IC50=8.16±1.04μM), 21 (IC50=8.4±0.15μM), 23 (IC50=9.0±0.35μM) and 13 (IC50=15.22±6.7μM) showed an excellent antiglycation activity far better than the standard (rutin, IC50=41.9±2.3μM). This study thus provides a series of potential molecules for further studies of antiglycation agents.
Elsevier
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