Hypothyroidism is one of the most commonly diagnosed endocrine disease in dogs. The
clinical signs are caused by a deficiency of the active thyroid hormones triiodothyronine (T3)
and thyroxine (T4) and have a negative impact on dog's quality of life. We hypothesized that
serum metabolic profile varies between healthy dogs and dogs with hypothyroidism. Twenty
serum samples from dogs with hypothyroidism and 20 from healthy dogs were used for
untargeted metabolomics analysis performed by LC/MS analysis. Fifteen metabolites …