Unusual bridged angucyclinones and potent anticancer compounds from Streptomyces bulli GJA1

JW Kim, Y Kwon, S Bang, HE Kwon, S Park… - Organic & …, 2020 - pubs.rsc.org
JW Kim, Y Kwon, S Bang, HE Kwon, S Park, Y Lee, ST Deyrup, G Song, D Lee, HS Joo
Organic & Biomolecular Chemistry, 2020pubs.rsc.org
Two new unique angucyclinones (1 and 2) with unprecedented ether bridges connecting
carbons 5 and 7 were isolated from the cultures of Streptomyces bulli GJA1, an endophyte of
Gardenia jasminoides, together with two known ones (3 and 4). The MS2-based molecular
networking system facilitated the isolation of compounds with target functionalities. The
stereochemistry of 1 was completely established by ROESY and ECD experiments.
Compound 3 showed antivirulence activities by inhibiting the peptide toxin (PSMs) …
Two new unique angucyclinones (1 and 2) with unprecedented ether bridges connecting carbons 5 and 7 were isolated from the cultures of Streptomyces bulli GJA1, an endophyte of Gardenia jasminoides, together with two known ones (3 and 4). The MS2-based molecular networking system facilitated the isolation of compounds with target functionalities. The stereochemistry of 1 was completely established by ROESY and ECD experiments. Compound 3 showed antivirulence activities by inhibiting the peptide toxin (PSMs) production and the biofilm formation of MRSA. Compounds 3 and 4 showed very potent anti-proliferative effects against OV1 and ES2 ovarian cancer cells.
The Royal Society of Chemistry
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