Up-regulation of MRP4 and down-regulation of influx transporters in human leukemic cells with acquired resistance to 6-mercaptopurine
XX Peng, Z Shi, VL Damaraju, XC Huang, GD Kruh… - Leukemia research, 2008 - Elsevier
To investigate the mechanism of cellular resistance to 6-MP, we established a 6-MP
resistant cell line (CEM-MP5) by stepwise selection of the human T-lymphoblastic leukemia
cell line (CEM). CEM-MP5 cells were about 100-fold resistant to 6-MP compared with
parental CEM cells. Western blot analysis demonstrated that multidrug resistant protein 4
(MRP4) was increased in CEM-MP5 cells, whereas the levels of the nucleoside transporters
hENT1, hCNT2 and hCNT3 were decreased compared with those of parental CEM cells …
resistant cell line (CEM-MP5) by stepwise selection of the human T-lymphoblastic leukemia
cell line (CEM). CEM-MP5 cells were about 100-fold resistant to 6-MP compared with
parental CEM cells. Western blot analysis demonstrated that multidrug resistant protein 4
(MRP4) was increased in CEM-MP5 cells, whereas the levels of the nucleoside transporters
hENT1, hCNT2 and hCNT3 were decreased compared with those of parental CEM cells …
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