Uric acid inhibits placental system A amino acid uptake

SA Bainbridge, F von Versen-Höynck, JM Roberts - Placenta, 2009 - Elsevier
Hyperuricemia, a common clinical characteristic of preeclamptic pregnancies, has
historically been considered a marker of reduced renal function in preeclamptic women.
More recently it has been suggested that uric acid may directly contribute to pathological cell
signaling events involved in disease progression as well as maternal and fetal pregnancy
outcomes including fetal growth restriction. We hypothesize that the increased frequency of
restricted fetal growth seen in relation to increasing uric acid concentrations in preeclamptic …
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