Background Recent studies have shown that urinary neutrophil gelatinase-associated
lipocalin (NGAL) is rapidly up-regulated early after murine renal injury, and in patients after
cardiac surgery or patients critically ill with multiple trauma. In this study, we evaluated
urinary NGAL levels as a potential biomarker of early acute kidney injury (AKI) in patients
with severe traumatic brain injury (TBI). Methods All patients with severe TBI admitted to our
neurosurgical intensive care unit from March to September 2011 were enrolled …

Introduction Serum creatinine is a late marker of acute kidney injury (AKI). Urine neutrophil
gelatinase-associated lipocalin (uNGAL) is an early marker of AKI, where the timing of
kidney injury is known. It is unknown whether uNGAL predicts AKI in the general critical care
setting. We assessed the ability of uNGAL to predict AKI development and severity in
critically ill children. Methods This was a prospective cohort study of critically ill children.
Children aged between 1 month and 21 years who were mechanically ventilated and had a …