Use of cDNA-expressed human cytochrome P450 enzymes to study potential drug-drug interactions
CL Crespi, BW Penman - Advances in pharmacology, 1997 - Elsevier
Publisher Summary cDNA-expressed enzymes can be used to study the cytochrome P450
form-selective inhibition by drugs or drug candidates. This analysis is accomplished through
the study of the inhibition of the metabolism of a model substrate by the drug or drug
candidate. Through these analyses, apparent K i values can be obtained and compared to K
i values for known, clinically significant inhibitors of the same enzyme. A coenzyme,
cytochrome P450 NADPH oxidoreductase (OR), is essential for P450 catalytic function, and …
form-selective inhibition by drugs or drug candidates. This analysis is accomplished through
the study of the inhibition of the metabolism of a model substrate by the drug or drug
candidate. Through these analyses, apparent K i values can be obtained and compared to K
i values for known, clinically significant inhibitors of the same enzyme. A coenzyme,
cytochrome P450 NADPH oxidoreductase (OR), is essential for P450 catalytic function, and …
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