[HTML][HTML] Use of photorefractive Keratectomy treated donor corneas for endothelial keratoplasty

ND Koseoglu, RM Nosé, P Hamrah - Journal of Ophthalmic & …, 2017 - ncbi.nlm.nih.gov
Journal of Ophthalmic & Vision Research, 2017ncbi.nlm.nih.gov
Editorial shown to be superior to other EKs, DSAEK remains the most frequently performed
EK technique.[1, 2] While full thickness PKP requires full thickness donor corneal tissues
without any anterior or posterior pathology, for EK the presence of a healthy endothelium is
sufficient. Therefore discarding donor corneas due to anterior scarring, pterygium, opacities,
history of previous corneal refractive surgery, etc., theoretically limits the availability of
tissues for EK cases but may not be necessary. Thus, theoretically, cornea of donors that …
Editorial shown to be superior to other EKs, DSAEK remains the most frequently performed EK technique.[1, 2] While full thickness PKP requires full thickness donor corneal tissues without any anterior or posterior pathology, for EK the presence of a healthy endothelium is sufficient. Therefore discarding donor corneas due to anterior scarring, pterygium, opacities, history of previous corneal refractive surgery, etc., theoretically limits the availability of tissues for EK cases but may not be necessary. Thus, theoretically, cornea of donors that have undergone refractive surgery could be used for EK. Radial keratotomy (RK), the first incisional refractive procedure, was widely popular in the 1980’s.[6] Later, with the development of excimer lasers, new surgical techniques such as photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK) were introduced into ophthalmic practice.[7] Thus, PRK rapidly replaced RK for treatment of myopia and is currently widely performed wordwide. The most frequent complication of PRK is subepithelial corneal haze. This complication occurs due to keratocyte mediated regrowth of the photoablated stroma. Therefore, in recent years LASIK has become the refractive surgery of choice. However, due to flap complications and higher frequency of post‑surgical neuralgia, PRK is undergoing a resurgence. The application of mitomycin–C (MMC) 0.02% in PRK cases for highly myopic eyes has been shown to reduce the risk of post‑surgical corneal haze by preventing the activity of corneal fibroblasts.[8, 9] However, controversies exist between studies in this regard, with some demonstrating that adjuvant use of mitomycin‑C in PRK can decrease endothelial cell density.[10‑12] Currently, the EBAA does not allow utilization of corneas with previous refractive surgeries for PKP, ALK and tectonic procedures. However, donor corneas with noninfectious anterior stromal opacities and pathology are permitted for endothelial keratoplasties.[13] The screening of donor corneas include the use of slit lamp
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