OBJECTIVE: The oral glucose tolerance test (OGTT) has often been used to evaluate
apparent insulin release and insulin resistance in various clinical settings. However,
because insulin sensitivity and insulin release are interdependent, to what extent they can
be predicted from an OGTT is unclear. RESEARCH DESIGN AND METHODS: We studied
insulin sensitivity using the euglycemic-hyperinsulinemic clamp and insulin release using
the hyperglycemic clamp in 104 nondiabetic volunteers who had also undergone an OGTT …

The oral glucose tolerance test (OGTT) has often been used to evaluate insulin secretion
and insulin resistance in various clinical settings. However, since insulin sensitivity and
insulin secretion are interdependent, it is unclear to what extent they can be predicted from
an OGTT. We therefore studied insulin sensitivity using the euglycemic-hyperinsulinemic
clamp and insulin secretion using the hyperglycemic clamp in 104 nondiabetic volunteers
who had also undergone an OGTT. Demographic parameters (body-mass index, waist-to …