[HTML][HTML] Using biomarkers to predict TB treatment duration (Predict TB): a prospective, randomized, noninferiority, treatment shortening clinical trial
Background: By the early 1980s, tuberculosis treatment was shortened from 24 to 6 months,
maintaining relapse rates of 1-2%. Subsequent trials attempting shorter durations have
failed, with 4-month arms consistently having relapse rates of 15-20%. One trial shortened
treatment only among those without baseline cavity on chest x-ray and whose month 2
sputum culture converted to negative. The 4-month arm relapse rate decreased to 7% but
was still significantly worse than the 6-month arm (1.6%, P< 0.01). We hypothesize that …
maintaining relapse rates of 1-2%. Subsequent trials attempting shorter durations have
failed, with 4-month arms consistently having relapse rates of 15-20%. One trial shortened
treatment only among those without baseline cavity on chest x-ray and whose month 2
sputum culture converted to negative. The 4-month arm relapse rate decreased to 7% but
was still significantly worse than the 6-month arm (1.6%, P< 0.01). We hypothesize that …
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