Untreated or poorly treated wastewater still represents environmental issues world-widely. Wastewater, especially saline wastewater treatment, is still primarily associated with high costs from physical and chemical processes, as high salinity hinders biological treatment. One favourable way is to find the suitable biological pathways and organisms to improve the biological treatment efficiency. In this context, halophilic microorganisms could be strong candidates to address the economics and effectiveness of the saline wastewater treatment process. Dunaliella salina is a photoautotrophic microalga that grows in saline environments. It is known for producing marketable bio-compounds such as carotenoids, lipids, and proteins. A biological treatment based on D. salina cultivation offers the opportunity to treat saline wastewater, reducing the threat of possible eutrophication from inappropriate discharge. At the same time, D. salina cultivation could yield compounds of industrial relevance to turn saline wastewater treatment into a profitable and sustainable process. Most research on D. salina has primarily focused on bioproduct generation, leaving thorough reviews of its application in wastewater treatment inadequate. This paper discusses the future challenges and opportunities of using D. salina to treat wastewater from different sources. The main conclusions are (1) D. salina effectively recovers some heavy metals (driven by metal binding capacity and exposure time) and nutrients (driven by pH, their bioavailability, and functional groups in the cell); (2) salinity plays a significant role in bioproducts generation, and (3) wastewater can be combined with the generation of bioproducts.