VapC21 Toxin Contributes to Drug-Tolerance and Interacts With Non-cognate VapB32 Antitoxin in Mycobacterium tuberculosis
The prokaryotic ubiquitous Toxin-antitoxin (TA) modules encodes for a stable toxin and an
unstable antitoxin. VapBC subfamily is the most abundant Type II TA system in M.
tuberculosis genome. However, the exact physiological role for most of these Type II TA
systems are still unknown. Here, we have comprehensively characterized the VapBC21 TA
locus from M. tuberculosis. The overexpression of VapC21 inhibited mycobacterial growth in
a bacteriostatic manner and as expected, growth inhibition was abrogated upon co …
unstable antitoxin. VapBC subfamily is the most abundant Type II TA system in M.
tuberculosis genome. However, the exact physiological role for most of these Type II TA
systems are still unknown. Here, we have comprehensively characterized the VapBC21 TA
locus from M. tuberculosis. The overexpression of VapC21 inhibited mycobacterial growth in
a bacteriostatic manner and as expected, growth inhibition was abrogated upon co …
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