Radiocarbon (14C) dating of archaeological coastal sites in arid areas is challenging because of the relative rarity of datable terrestrial artefacts. Marine artefacts provide an abundant source of carbon, which is technically easy to date but radiocarbon dates need to be corrected for local variations from the global average marine 14C reservoir age (ΔR). In archaeological sites, this is usually done by the comparison of the 14C age measured between coeval pairs of terrestrial and marine samples that have no inbuilt age. Here, we present the results of a study that aims to determine the local 14C marine reservoir effect (MRE) along the Eastern coast of the Arabic Peninsula during the 4th millennium BC, a period of important cultural, demographic and social changes in this region. Previous estimates of the MRE based on associated shells and charcoal vary by about 400 14C yr and this is a serious limitation to the establishment of a precise chronology in the area based on marine material. In order to maximize the chances to obtain contemporaneous terrestrial–marine pairs for a new assessment of the MRE in this region we dated charcoal, shells, fish and turtle bones as well as human bones found in three recently and carefully excavated graves from Ra’s al-Hamra RH5. A large variability was found between charcoals (up to 240 14C yr) and marine specimens (up to 785 14C yr) present in the same grave. This variability was attributed to inbuilt ages, diagenesis and possibly environmental factors although taphonomic processes cannot be excluded. We discarded the oldest charcoals and used the 14C ages obtained on human apatite as a cut-off value to remove the marine outliers. Two out of the three graves provided terrestrial and marine assemblages which did not differ statistically and were used to calculate an average MRE of 645 ± 40 14C yr (ΔR = 255 ± 55 14C yr). This value is consistent with previous estimates based on the 14C dating of marine sediments off Pakistan and suggests stability of the MRE in the Arabian Sea since the 4th millennium BC.