[HTML][HTML] Variability of CubeQuant T1ρ, quantitative DESS T2, and cones sodium MRI in knee cartilage
Osteoarthritis and cartilage, 2014•Elsevier
Objective To measure the variability of T 1ρ relaxation times using CubeQuant, T 2
relaxation times using quantitative double echo in steady state (DESS), and normalized
sodium signals using 3D cones sodium magnetic resonance imaging (MRI) of knee cartilage
in vivo at 3 T. Design Eight healthy subjects were scanned at 3 T at baseline, 1 day, 5
months, and 1 year. Ten regions of interest (ROIs) of knee cartilage were segmented in the
medial and lateral compartments of each subject's knee. T 1ρ and T 2 relaxation times and …
relaxation times using quantitative double echo in steady state (DESS), and normalized
sodium signals using 3D cones sodium magnetic resonance imaging (MRI) of knee cartilage
in vivo at 3 T. Design Eight healthy subjects were scanned at 3 T at baseline, 1 day, 5
months, and 1 year. Ten regions of interest (ROIs) of knee cartilage were segmented in the
medial and lateral compartments of each subject's knee. T 1ρ and T 2 relaxation times and …
Objective
To measure the variability of T1ρ relaxation times using CubeQuant, T2 relaxation times using quantitative double echo in steady state (DESS), and normalized sodium signals using 3D cones sodium magnetic resonance imaging (MRI) of knee cartilage in vivo at 3 T.
Design
Eight healthy subjects were scanned at 3 T at baseline, 1 day, 5 months, and 1 year. Ten regions of interest (ROIs) of knee cartilage were segmented in the medial and lateral compartments of each subject's knee. T1ρ and T2 relaxation times and normalized sodium signals were measured and the root-mean-square coefficient of variation (CVRMS) was calculated. Intra-subject variability was measured over short, moderate and long-term, as well as intra-observer and inter-observer variability.
Results
The average intra-subject CVRMS measurements over short, moderate, and long-term time periods were 4.6%, 6.1%, and 6.0% for the T1ρ measurements, 6.4%, 9.3%, and 10.7% for the T2 measurements and 11.3%, 11.6%, and 12.9% for the sodium measurements, respectively. The average CVRMS measurements for intra-observer and inter-observer segmentation were 3.8% and 5.7% for the T1ρ measurements, 4.7% and 6.7% for the T2 measurements, and 8.1% and 11.4% for the sodium measurements, respectively.
Conclusions
These CVRMS measurements are substantially lower than previously measured changes expected in patients with advanced osteoarthritis compared to healthy volunteers, suggesting that CubeQuant T1ρ, quantitative DESS T2 and 3D cones sodium measurements are sufficiently sensitive for in vivo cartilage studies.
Elsevier
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