We conducted a randomized, double-blind, parallel-group study to assess the effect of 6
weeks treatment with low-dose (100 μg twice a day) or high-dose (500 μg twice a day)
inhaled fluticasone propionate (FP) on the vascular component of airway remodeling in 30
patients with mild to moderate asthma. We also studied the effect on the inflammatory cells
and the basement membrane thickness, and we compared findings from bronchial biopsies
taken in patients with asthma with those in eight control subjects. Bronchial responsiveness …

Methods. Questionnaires were sent to the physicians, asking whether they had encountered
asthmatic patients with acute adrenal crises associated with ICS use. Physicians who
responded positively completed a more detailed questionnaire. Patients receiving orally
administered corticosteroids were excluded, and the case definition required both symptoms
of an adrenal crisis and abnormal hypothalamic-pituitary-adrenal axis function test results.
Results. Thirty-three patients met the case definition criteria for acute adrenal crises …