As a twofold Michael system, the diarylideneacetone core is of particular interest in organic
synthesis and for therapeutic applications. To overcome the drawbacks of the classical
Claisen–Schmidt protocol, a new methodology for the synthesis of dissymmetric (hetero)
diarylideneacetones has been developed. Conditions were optimized with a Box–Behnken
design of experiment. The milder reaction conditions allow the efficient preparation of
fluorinated, or heteroaromatic, dissymmetric diarylideneacetones which cannot be obtained …

In Scheme 3, page 3830, the authors have noticed a mistake, which unfortunately has been
overlooked upon checking the galley proofs. Compound 2a is falsely drawn as a propargyl
ketone instead of being a propargyl alcohol, as it should be. The correct scheme is shown
below.