Visible-light-activated asymmetric β-C–H functionalization of acceptor-substituted ketones with 1, 2-dicarbonyl compounds
We report a visible-light-activated asymmetric β-C (sp3)–H functionalization of 2-acyl
imidazoles and 2-acylpyridines with 1, 2-dicarbonyl compounds (typically α-ketoesters)
catalyzed by a tailored stereogenic-at-rhodium Lewis acid catalyst. The C–C bond formation
products are obtained in high yields (up to 99%) and with excellent stereoselectivities (up
to> 20: 1 dr and up to> 99% ee). Experimental and computational studies support a
mechanism in which a photoactivated Rh-enolate transfers a single electron to the 1, 2 …
imidazoles and 2-acylpyridines with 1, 2-dicarbonyl compounds (typically α-ketoesters)
catalyzed by a tailored stereogenic-at-rhodium Lewis acid catalyst. The C–C bond formation
products are obtained in high yields (up to 99%) and with excellent stereoselectivities (up
to> 20: 1 dr and up to> 99% ee). Experimental and computational studies support a
mechanism in which a photoactivated Rh-enolate transfers a single electron to the 1, 2 …
[引用][C] Visible-Light-Activated Asymmetric β-C–H Functionalization of Acceptor-Substituted Ketones with 1, 2-Dicarbonyl Compounds
M Jiajia, H Xiaoqiang, H Klaus, R Radostan, W Olaf… - 2017
以上显示的是最相近的搜索结果。 查看全部搜索结果