Voriconazole suppresses the growth of Leishmania species in vitro
MM Kulkarni, N Reddy, T Gude, BS McGwire - Parasitology research, 2013 - Springer
MM Kulkarni, N Reddy, T Gude, BS McGwire
Parasitology research, 2013•SpringerThe digenetic protozoan Leishmania is dependent on ergosterol synthesis for growth and
viability. We compared the in vitro activity of ergosterol synthesis inhibitor voriconazole with
fluconazole and ketoconazole against cutaneous and visceral Leishmania species. We
found the IC 50 of voriconazole was comparable to ketoconazole and both were superior to
fluconazole. Both ketoconazole and voriconazole were active against insect and
mammalian stage parasites. This is the first report of the in vitro activity of voriconazole …
viability. We compared the in vitro activity of ergosterol synthesis inhibitor voriconazole with
fluconazole and ketoconazole against cutaneous and visceral Leishmania species. We
found the IC 50 of voriconazole was comparable to ketoconazole and both were superior to
fluconazole. Both ketoconazole and voriconazole were active against insect and
mammalian stage parasites. This is the first report of the in vitro activity of voriconazole …
Abstract
The digenetic protozoan Leishmania is dependent on ergosterol synthesis for growth and viability. We compared the in vitro activity of ergosterol synthesis inhibitor voriconazole with fluconazole and ketoconazole against cutaneous and visceral Leishmania species. We found the IC50 of voriconazole was comparable to ketoconazole and both were superior to fluconazole. Both ketoconazole and voriconazole were active against insect and mammalian stage parasites. This is the first report of the in vitro activity of voriconazole against leishmanial species.
Springer
以上显示的是最相近的搜索结果。 查看全部搜索结果