For its size, the brain is the most metabolically active organ in the body. Most of its energy
demand is used to maintain stable homeostatic physiological conditions. Altered
homeostasis and active states are hallmarks of many diseases and disorders. Yet there is
currently no direct and reliable method to assess homeostasis and absolute basal activity of
cells in the tissue noninvasively without exogenous tracers or contrast agents. We propose a
novel low-field, high-gradient diffusion exchange nuclear magnetic resonance (NMR) …