Bladder cancer is one of the most common cancers worldwide, with transitional cell
carcinoma (TCC) being the predominant form. Here we report a genomic analysis of TCC by
both whole-genome and whole-exome sequencing of 99 individuals with TCC. Beyond
confirming recurrent mutations in genes previously identified as being mutated in TCC, we
identified additional altered genes and pathways that were implicated in TCC. Notably, we
discovered frequent alterations in STAG2 and ESPL1, two genes involved in the sister …

Re: whole-genome and whole-exome sequencing of bladder cancer identifies frequent
alterations in genes involved in sister chromatid cohesion and segregation. - Abstract - Europe
PMC … Re: whole-genome and whole-exome sequencing of bladder cancer identifies frequent
alterations in genes involved in sister chromatid cohesion and segregation. … Urology
Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA. …