Wnt/β-catenin signaling regulated SATB1 promotes colorectal cancer tumorigenesis and progression
The chromatin organizer SATB1 has been implicated in the development and progression of
multiple cancers including breast and colorectal cancers. However, the regulation and role
of SATB1 in colorectal cancers is poorly understood. Here, we demonstrate that expression
of SATB1 is induced upon hyperactivation of Wnt/β-catenin signaling and repressed upon
depletion of TCF7L2 (TCF4) and β-catenin. Using several colorectal cancer cell line models
and the APC min mutant zebrafish in vivo model, we established that SATB1 is a novel …
multiple cancers including breast and colorectal cancers. However, the regulation and role
of SATB1 in colorectal cancers is poorly understood. Here, we demonstrate that expression
of SATB1 is induced upon hyperactivation of Wnt/β-catenin signaling and repressed upon
depletion of TCF7L2 (TCF4) and β-catenin. Using several colorectal cancer cell line models
and the APC min mutant zebrafish in vivo model, we established that SATB1 is a novel …
Wnt/β-catenin signaling regulated SATB1 promotes colorectal cancer tumorigenesis and progression
The chromatin organizer SATB1 has been implicated in the development and progression of
multiple cancers including breast and colorectal cancers. However, the regulation and role
of SATB1 in colorectal cancers is poorly understood. Here, we demonstrate that expression
of SATB1 is induced upon hyperactivation of Wnt/β-catenin signaling and repressed upon
depletion of TCF7L2 (TCF4) and β-catenin. Using several colorectal cancer cell line models
and the APC min mutant zebrafish in vivo model, we established that SATB1 is a novel …
multiple cancers including breast and colorectal cancers. However, the regulation and role
of SATB1 in colorectal cancers is poorly understood. Here, we demonstrate that expression
of SATB1 is induced upon hyperactivation of Wnt/β-catenin signaling and repressed upon
depletion of TCF7L2 (TCF4) and β-catenin. Using several colorectal cancer cell line models
and the APC min mutant zebrafish in vivo model, we established that SATB1 is a novel …