The potency of Ocimum gratissimum L. as a wound healing agent was investigated with a view to develop a drug that is readily available, affordable and accessible to the rural farmers. Thirty (30) Albino Wistar rats weighing 180-200g were grouped into six (AF). Each animal in the group was anaesthetised using chloroform. The part of their hind leg (thigh) was shaved using a very sharp and sterilised surgical blade. Thereafter, a surgical blade and a forceps were employed to create an external nosa (wound) of a known diameter. Group A was the standard control treated with 0.5 g of penicillin ointment, while the remaining groups were treated with 0.25, 0.50, 0.75 and 1.00 g/ml of the extract respectively and group F was the negative control treated with distilled water. The treatment was carried out on daily basis for a period of 3 weeks. All doses (except 50mg/ml) showed a significant reduction (P< 0.05) in the wound diameter on the third day of the extract administration/application. Occimum gratissimum can be packaged and employed as a phyto-agent against external nosa in farm animals.