Xenopus transcription factor A requires zinc for binding to the 5 S RNA gene.
JS Hanas, DJ Hazuda, DF Bogenhagen, FY Wu… - Journal of Biological …, 1983 - ASBMB
Transcription factor A from immature Xenopus oocytes is found associated with 5 S RNA in a
7 S nucleoprotein complex. Atomic absorption analysis of EDTA-dialyzed 7 S particles
reveals 2 mol of zinc/mol of particle. Factor A obtained from EDTA-dialyzed particles binds
specifically to the 5 S RNA gene as determined by DNase I footprinting. Factor A alone,
obtained by RNase digestion of the 7 S particle, contains zinc when dialyzed in the absence
of EDTA. However, the zinc bound to free factor A is removed by dialysis against a buffer …
7 S nucleoprotein complex. Atomic absorption analysis of EDTA-dialyzed 7 S particles
reveals 2 mol of zinc/mol of particle. Factor A obtained from EDTA-dialyzed particles binds
specifically to the 5 S RNA gene as determined by DNase I footprinting. Factor A alone,
obtained by RNase digestion of the 7 S particle, contains zinc when dialyzed in the absence
of EDTA. However, the zinc bound to free factor A is removed by dialysis against a buffer …
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