Yb (OTf) 3-catalyzed addition of 2-methyl azaarenes to isatins via CH functionalization

NIU Rui, Y Shiying, X Jian, T LIANG… - Chinese Journal of …, 2012 - Elsevier
NIU Rui, Y Shiying, X Jian, T LIANG, LI Xingwei
Chinese Journal of Catalysis, 2012Elsevier
3-Substituted-3-hydroxy-2-oxindoles are rich in a range of biologically active natural
products and pharmaceuticals and development of efficient methods to construct this key
motif is of vital importance. Yb (OTf) 3-catalyzed addition of 2-or 4-methyl azaarenes to
isatins via CH functionalization was developed. Moderate to good yields were obtained for
various isatins and azaarenes. This method provides rapid protocol for the synthesis of
biologically important azaarene-substituted 3-hydroxy-2-oxindoles in one step. The success …
3-Substituted-3-hydroxy-2-oxindoles are rich in a range of biologically active natural products and pharmaceuticals and development of efficient methods to construct this key motif is of vital importance. Yb(OTf)3-catalyzed addition of 2- or 4-methyl azaarenes to isatins via C-H functionalization was developed. Moderate to good yields were obtained for various isatins and azaarenes. This method provides rapid protocol for the synthesis of biologically important azaarene-substituted 3-hydroxy-2-oxindoles in one step. The success of this reaction expands the synthetic utility of Lewis acid in the catalytic functionalization of sp3 C-H bonds in organic synthesis.
Elsevier
以上显示的是最相近的搜索结果。 查看全部搜索结果