Yeast life-span extension by calorie restriction is independent of NAD fluctuation
RM Anderson, M Latorre-Esteves, AR Neves, S Lavu… - Science, 2003 - science.org
RM Anderson, M Latorre-Esteves, AR Neves, S Lavu, O Medvedik, C Taylor, KT Howitz…
Science, 2003•science.orgCalorie restriction (CR) slows aging in numerous species. In the yeast Saccharomyces
cerevisiae, this effect requires Sir2, a conserved NAD+-dependent deacetylase. We report
that CR reduces nuclear NAD+ levels in vivo. Moreover, the activity of Sir2 and its human
homologue SIRT1 are not affected by physiological alterations in the NAD+: NADH ratio.
These data implicate alternate mechanisms of Sir2 regulation by CR.
cerevisiae, this effect requires Sir2, a conserved NAD+-dependent deacetylase. We report
that CR reduces nuclear NAD+ levels in vivo. Moreover, the activity of Sir2 and its human
homologue SIRT1 are not affected by physiological alterations in the NAD+: NADH ratio.
These data implicate alternate mechanisms of Sir2 regulation by CR.
Calorie restriction (CR) slows aging in numerous species. In the yeast Saccharomyces cerevisiae, this effect requires Sir2, a conserved NAD+-dependent deacetylase. We report that CR reduces nuclear NAD+ levels in vivo. Moreover, the activity of Sir2 and its human homologue SIRT1 are not affected by physiological alterations in the NAD+:NADH ratio. These data implicate alternate mechanisms of Sir2 regulation by CR.
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