Zearalenone (ZEA)-induced intestinal inflammation is mediated by the NLRP3 inflammasome
To ascertain whether zearalenone (ZEA) could induce intestinal inflammation and
investigate its possible mechanism, we investigated inflammatory cytokine release and the
activation of the NLRP3 inflammasome after ZEA treatment both in vitro or in vivo. First,
intestinal porcine enterocyte cell line (IPEC-J2) cells and mouse peritoneal macrophages
were treated with ZEA to detect NLRP3 inflammasome activation, and the role of reactive
oxygen species (ROS) in ZEA-induced inflammation was investigated. Then, Balb/c mice …
investigate its possible mechanism, we investigated inflammatory cytokine release and the
activation of the NLRP3 inflammasome after ZEA treatment both in vitro or in vivo. First,
intestinal porcine enterocyte cell line (IPEC-J2) cells and mouse peritoneal macrophages
were treated with ZEA to detect NLRP3 inflammasome activation, and the role of reactive
oxygen species (ROS) in ZEA-induced inflammation was investigated. Then, Balb/c mice …
Zearalenone (ZEA)-induced intestinal inflammation is mediated by the NLRP3 inflammasome.
FWT Fan WenTao, LYN Lv YaNan, RS Ren Shuai… - 2018 - cabidigitallibrary.org
To ascertain whether zearalenone (ZEA) could induce intestinal inflammation and
investigate its possible mechanism, we investigated inflammatory cytokine release and the
activation of the NLRP3 inflammasome after ZEA treatment both in vitro or in vivo. First,
intestinal porcine enterocyte cell line (IPEC-J2) cells and mouse peritoneal macrophages
were treated with ZEA to detect NLRP3 inflammasome activation, and the role of reactive
oxygen species (ROS) in ZEA-induced inflammation was investigated. Then, Balb/c mice …
investigate its possible mechanism, we investigated inflammatory cytokine release and the
activation of the NLRP3 inflammasome after ZEA treatment both in vitro or in vivo. First,
intestinal porcine enterocyte cell line (IPEC-J2) cells and mouse peritoneal macrophages
were treated with ZEA to detect NLRP3 inflammasome activation, and the role of reactive
oxygen species (ROS) in ZEA-induced inflammation was investigated. Then, Balb/c mice …
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