Zinc deficiency suppresses matrix mineralization and retards osteogenesis transiently with catch-up possibly through Runx 2 modulation
A characteristic sign of zinc deficiency is retarded skeletal growth, but the role of zinc in
osteoblasts is not well understood. Two major events for bone formation include osteoblast
differentiation by bone marker gene expression, which is mainly regulated by bone-specific
transcription factor Runx2 and extracellular matrix (ECM) mineralization by Ca deposits for
bone nodule formation. We investigated whether zinc deficiency down-regulates bone
marker gene transcription and whether this might occur through modulation of Runx2. We …
osteoblasts is not well understood. Two major events for bone formation include osteoblast
differentiation by bone marker gene expression, which is mainly regulated by bone-specific
transcription factor Runx2 and extracellular matrix (ECM) mineralization by Ca deposits for
bone nodule formation. We investigated whether zinc deficiency down-regulates bone
marker gene transcription and whether this might occur through modulation of Runx2. We …
Zinc deficiency suppresses matrix mineralization and retards osteogenesis transiently with catch-up possibly through Runx 2 modulation.
KIS Kwun InSook, CYE Cho YoungEun, RAR Lomeda… - 2010 - cabidigitallibrary.org
A characteristic sign of zinc deficiency is retarded skeletal growth, but the role of zinc in
osteoblasts is not well understood. Two major events for bone formation include osteoblast
differentiation by bone marker gene expression, which is mainly regulated by bone-specific
transcription factor Runx2 and extracellular matrix (ECM) mineralization by Ca deposits for
bone nodule formation. We investigated whether zinc deficiency down-regulates bone
marker gene transcription and whether this might occur through modulation of Runx2. We …
osteoblasts is not well understood. Two major events for bone formation include osteoblast
differentiation by bone marker gene expression, which is mainly regulated by bone-specific
transcription factor Runx2 and extracellular matrix (ECM) mineralization by Ca deposits for
bone nodule formation. We investigated whether zinc deficiency down-regulates bone
marker gene transcription and whether this might occur through modulation of Runx2. We …
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