X Fang, J Gao, H Zheng, B Li, L Kong… - Journal of medical …, 2007 - Wiley Online Library
… (M) protein of SARSCoV physically interacted with IKKb … (TNFa) induced NF-kB activation using a luciferase reporter assay. … results indicate that SARS-CoV M suppresses NF-kB activity …
… and characterize SARS-CoV-2 proteins that were able to modulate NF-κB response and … proteins of SARS-CoV-2 are NF-κB activators. No significant difference was found in NF-κB …
W Wang, L Ye, L Ye, B Li, B Gao, Y Zeng, L Kong… - Virus research, 2007 - Elsevier
… To further confirm that S protein can activateNF-κB, we analyzed I-κBα by Western blotting. I-κBα was found to be decreased by 30% after incubation with purified S protein for 1.5 h, …
Q Ma, W Pan, R Li, B Liu, C Li, Y Xie, Z Wang… - Pharmacological …, 2020 - Elsevier
… infection, the regulation of the NF-кB/MAPK … SARS-CoV-2 activated the NF-кB /MAPK signaling pathway and LS could significantly decrease SARS-CoV-2-induced activation of p-NF-κB …
W Li, J Qiao, Q You, S Zong, Q Peng, Y Liu… - Frontiers in …, 2021 - frontiersin.org
… SARS-CoV-2 Nsp5 can elevate the expression of inflammatory cytokines by activating the NF-κB … increased levels of MAVS protein and activation of NF-κB signaling pathway. This study …
… TLR2 dimerizes with TLR1 or TLR6 to activate the NF-κB pathway. Taken together, these … SARS-CoV-2 infection and suggest that TLR2 could be a potential therapeutic target for COVID…
H Nishitsuji, S Iwahori, M Ohmori, K Shimotohno… - MBio, 2022 - Am Soc Microbiol
… In this study, we screened 22 SARS-CoV-2 proteins for their ability to activateNF-κB … induced NF-κBactivation and increased IL-8 and IP-10 mRNA expression in a TAK1- and NF-κB …
SF Dosch, SD Mahajan, AR Collins - Virus research, 2009 - Elsevier
… Activation and translocation of NF-κB was shown to occur rapidly … nuclear NF-κB p65 transcription factor. The results further suggested that released or secreted S protein could activate …
X Zhang, K Wu, D Wang, X Yue, D Song, Y Zhu, J Wu - Virology, 2007 - Elsevier
… that SARS-CoV N protein plays a role in the activation of IL-6. To further determine the roles of different regions of N protein in the activation of IL… of these mutants in the activation of IL-6. …