Activation of NFκB by the full‐length nucleocapsid protein of the SARS coronavirus

QJ LIAO, LB YE, KA Timani, YC ZENG… - Acta biochimica et …, 2005 - Wiley Online Library
… between the SARS-CoV nucleocapsid (N) protein and NF-κB by … that the SARS-CoV N
protein can significantly activate NF-κB only in Vero E6 cells, which are susceptible to SARS-CoV

The membrane protein of SARSCoV suppresses NFκB activation

X Fang, J Gao, H Zheng, B Li, L Kong… - Journal of medical …, 2007 - Wiley Online Library
… (M) protein of SARSCoV physically interacted with IKKb … (TNFa) induced NF-kB activation
using a luciferase reporter assay. … results indicate that SARS-CoV M suppresses NF-kB activity …

Activation of NF-κB and induction of proinflammatory cytokine expressions mediated by ORF7a protein of SARS-CoV-2

CM Su, L Wang, D Yoo - Scientific reports, 2021 - nature.com
… and characterize SARS-CoV-2 proteins that were able to modulate NF-κB response and …
proteins of SARS-CoV-2 are NF-κB activators. No significant difference was found in NF-κB

Up-regulation of IL-6 and TNF-α induced by SARS-coronavirus spike protein in murine macrophages via NF-κB pathway

W Wang, L Ye, L Ye, B Li, B Gao, Y Zeng, L Kong… - Virus research, 2007 - Elsevier
… To further confirm that S protein can activate NF-κB, we analyzed I-κBα by Western blotting.
I-κBα was found to be decreased by 30% after incubation with purified S protein for 1.5 h, …

Liu Shen capsule shows antiviral and anti-inflammatory abilities against novel coronavirus SARS-CoV-2 via suppression of NF-κB signaling pathway

Q Ma, W Pan, R Li, B Liu, C Li, Y Xie, Z Wang… - Pharmacological …, 2020 - Elsevier
… infection, the regulation of the NF-кB/MAPK … SARS-CoV-2 activated the NF-кB /MAPK
signaling pathway and LS could significantly decrease SARS-CoV-2-induced activation of p-NF-κB

[HTML][HTML] SARS-CoV-2 Nsp5 activates NF-κB pathway by upregulating SUMOylation of MAVS

W Li, J Qiao, Q You, S Zong, Q Peng, Y Liu… - Frontiers in …, 2021 - frontiersin.org
SARS-CoV-2 Nsp5 can elevate the expression of inflammatory cytokines by activating the
NF-κB … increased levels of MAVS protein and activation of NF-κB signaling pathway. This study …

SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathway

S Khan, MS Shafiei, C Longoria, JW Schoggins… - Elife, 2021 - elifesciences.org
… TLR2 dimerizes with TLR1 or TLR6 to activate the NF-κB pathway. Taken together, these …
SARS-CoV-2 infection and suggest that TLR2 could be a potential therapeutic target for COVID

Ubiquitination of SARS-CoV-2 NSP6 and ORF7a facilitates NF-κB activation

H Nishitsuji, S Iwahori, M Ohmori, K Shimotohno… - MBio, 2022 - Am Soc Microbiol
… In this study, we screened 22 SARS-CoV-2 proteins for their ability to activate NF-κB
induced NF-κB activation and increased IL-8 and IP-10 mRNA expression in a TAK1- and NF-κB

SARS coronavirus spike protein-induced innate immune response occurs via activation of the NF-κB pathway in human monocyte macrophages in vitro

SF Dosch, SD Mahajan, AR Collins - Virus research, 2009 - Elsevier
Activation and translocation of NF-κB was shown to occur rapidly … nuclear NF-κB p65
transcription factor. The results further suggested that released or secreted S protein could activate

[HTML][HTML] Nucleocapsid protein of SARS-CoV activates interleukin-6 expression through cellular transcription factor NF-κB

X Zhang, K Wu, D Wang, X Yue, D Song, Y Zhu, J Wu - Virology, 2007 - Elsevier
… that SARS-CoV N protein plays a role in the activation of IL-6. To further determine the roles
of different regions of N protein in the activation of IL… of these mutants in the activation of IL-6. …