Application of small RNA sequencing to identify microRNAs in acute kidney injury and fibrosis

KL Pellegrini, CV Gerlach, FL Craciun… - Toxicology and applied …, 2016 - Elsevier
small RNA sequencing to profile miRNAs expressed during injury and fibrotic phases of kidney
damage. … acute stage of the injury, miR-132-3p is upregulated during transition between …

Urinary extracellular vesicles and micro-RNA as markers of acute kidney injury after cardiac surgery

D Miller, B Eagle-Hemming, S Sheikh, L Joel-David… - Scientific Reports, 2022 - nature.com
… To identify AKI-specific miR, we sequenced RNA isolated from urinary extracellular vesicles.
The analysis included five patients with AKI and five without. To avoid heterogeneity in such …

[HTML][HTML] … analysis of the expression profile of non-coding RNAs involved in ischemia/reperfusion-induced acute kidney injury in mice using RNA sequencing

J Zhou, H Chen, Y Fan - Oncotarget, 2017 - ncbi.nlm.nih.gov
… In this study, we utilized an RNA sequencing approach to investigate ncRNAs in the kidneys
of mouse … Sequencing libraries of small RNA were generated using an NEBNext® Multiplex …

Transcriptome sequencing of circular RNA reveals a novel circular RNA-has_circ_0114427 in the regulation of inflammation in acute kidney injury

Y Cao, X Mi, D Zhang, Z Wang, Y Zuo… - Clinical Science, 2020 - portlandpress.com
Acute kidney injury (AKI) is a complicated disease characterized by a rapid decrease in
glomerular filtration rate (GFR) and an increase in serum creatinine. The mortality rate in patients …

Single cell RNA sequencing identifies a unique inflammatory macrophage subset as a druggable target for alleviating acute kidney injury

W Yao, Y Chen, Z Li, J Ji, A You, S Jin, Y Ma… - Advanced …, 2022 - Wiley Online Library
Acute kidney injury (AKI) is a clinical syndrome with complex pathogenesis and limited …
[ 1 ] Severe AKI can be life-threatening and increases the risk of chronic kidney disease (CKD) …

[HTML][HTML] Noncoding RNAs in acute kidney injury

T Brandenburger, AS Somoza, Y Devaux… - Kidney International, 2018 - Elsevier
Small RNA sequencing and whole genome expression analysis revealed only minor
changes between MALAT1 knockout and wild-type mice. Contrary to previous studies, an in vivo …

Non-coding RNA-associated ceRNA networks in a new contrast-induced acute kidney injury rat model

W Cheng, XW Li, YQ Xiao, SB Duan - Molecular Therapy-Nucleic Acids, 2019 - cell.com
… In this study, we developed whole-transcriptome sequencing (RNA sequencing [RNA-seq])
with the Illumina HiSeq 2000 and HiSeq 4000 in a control group and a new CI-AKI rat model …

Comprehensive analysis of ceRNA network composed of circRNA, miRNA, and mRNA in septic acute kidney injury patients based on RNA-seq

SR Ma, Q Ma, YN Ma, WJ Zhou - Frontiers in Genetics, 2023 - frontiersin.org
… To sequence small RNAs, using miRDeep2, we compared the sequences of small RNAs of
each sample with those of miRNA precursors and mature miRNAs of corresponding species …

Gene expression profiling of sepsis‑associated acute kidney injury

JJ Yang, BB Wu, F Han… - Experimental and …, 2020 - spandidos-publications.com
… Sepsis accounts for more than 50% of all acute kidney injury (… gene expression profiles using
RNA sequencing (RNASeq) and … of SA‑AKI using RNASeq, which provides some basis for …

RNA-Seq identifies condition-specific biological signatures of ischemia-reperfusion injury in the human kidney

M Park, CH Kwon, HK Ha, M Han, SH Song - BMC nephrology, 2020 - Springer
… strategy may be necessary to prevent severe kidney damage after IRI in the clinical setting.
Although our study has limitations such as the small number of samples and relatively short …