[HTML][HTML] Regulation of the NLRP3 inflammasome and macrophage pyroptosis by the p38 MAPK signaling pathway in a mouse model of acute lung injury

D Li, W Ren, Z Jiang, L Zhu - Molecular medicine …, 2018 - spandidos-publications.com
… pathway in macrophage pyroptosis and uncontrolled lung … In the present study, two
macrophage cell lines and an ALI/… macrophage pyroptosis and LPS-induced acute lung injury

Inhibition of alveolar macrophage pyroptosis reduces lipopolysaccharide-induced acute lung injury in mice

DD Wu, PH Pan, B Liu, XL Su, LM Zhang… - Chinese Medical …, 2015 - journals.lww.com
macrophage (AM) pyroptosis in the pathogenesis of the acute lung injury and acute
respiratory … This study reported AM pyroptosis during LPS-induced ALI/ARDS in mice and has …

[HTML][HTML] Ligustrazine alleviate acute lung injury through suppressing pyroptosis and apoptosis of alveolar macrophages

R Jiang, J Xu, Y Zhang, X Zhu, J Liu… - Frontiers in …, 2021 - frontiersin.org
… the polarization of M1-type macrophages, and to a certain … to reduced cell pyroptosis and
accompanying inflammation. TMP … reversed macrophages polarization, reduced cell pyroptosis

[HTML][HTML] Inflammatory caspases drive pyroptosis in acute lung injury

B Liu, R He, L Zhang, B Hao, W Jiang… - Frontiers in …, 2021 - frontiersin.org
… In conclusion, alveolar macrophage pyroptosis may be involved in the development of
acute lung injury and NLRP3/ASC inflammasomes participate in the process (Wu et al., 2015). …

[HTML][HTML] Interferon regulatory factor-1 mediates alveolar macrophage pyroptosis during LPS-induced acute lung injury in mice

D Wu, P Pan, X Su, L Zhang, Q Qin, H Tan, L Huang… - Shock, 2016 - journals.lww.com
pyroptosis in alveolar macrophages (AMs) plays an essential role in lipopolysaccharide (LPS)-induced
acute lung injury. … pyroptosis in AMs and alleviates the LPS-induced lung injury

Memantine alleviates acute lung injury via inhibiting macrophage pyroptosis

H Ding, J Yang, L Chen, Y Li, G Jiang, J Fan - Shock, 2021 - journals.lww.com
… suppresses macrophage pyroptosis and subsequent attenuating lung inflammation, we
tested direct effect of memantine on macrophage pyroptosis using in vitro BMDM pyroptosis

Pyroptosis and polarization of macrophages in septic acute lung injury induced by lipopolysaccharide in mice

S Zhou, X Yang, K Mo, Z Ning - … , Inflammation and Disease, 2024 - Wiley Online Library
… Starting from the inflammatory cell mechanism, this study investigates the impact of
alveolar macrophage pyroptosis on polarization during ALI caused by sepsis in mice and its …

[HTML][HTML] NLRP3/ASC-mediated alveolar macrophage pyroptosis enhances HMGB1 secretion in acute lung injury induced by cardiopulmonary bypass

L Hou, Z Yang, Z Wang, X Zhang, Y Zhao, H Yang… - Laboratory …, 2018 - Elsevier
Acute lung injury is a serious side effect of cardiopulmonary bypass. This study reveals that
macrophage pyroptosis increases high-mobility group box 1 secretion in acute lung injury

[HTML][HTML] Exosomal miR-30d-5p of neutrophils induces M1 macrophage polarization and primes macrophage pyroptosis in sepsis-related acute lung injury

Y Jiao, T Zhang, C Zhang, H Ji, X Tong, R Xia, W Wang… - Critical Care, 2021 - Springer
… Next, we wanted to determine through which pathway TNF-Exo promoted M1 macrophage
activation and primed macrophage pyroptosis in vitro by co-culturing macrophages with …

[HTML][HTML] Caspase-1-mediated extracellular vesicles derived from pyroptotic alveolar macrophages promote inflammation in acute lung injury

X Qin, Y Zhou, C Jia, Z Chao, H Qin… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
… of acute lung injury (ALI) involve a variety of pathological factors and complex mechanisms.
How pulmonary … a mass production of 1-5 μm pyroptotic bodies (PyrBDs) release in the early …