Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques

NB Mercado, R Zahn, F Wegmann, C Loos… - Nature, 2020 - nature.com
… a single immunization of Ad26 vector-based vaccines for SARS-CoV-2 elicited robust
neutralizing antibody titres and provided complete or near-complete protection against SARS-CoV-…

Immunogenicity of Ad26. COV2. S vaccine against SARS-CoV-2 variants in humans

G Alter, J Yu, J Liu, A Chandrashekar, EN Borducchi… - Nature, 2021 - nature.com
… this vaccine in humans against SARS-CoV-2 variants of concern remains unclear. Here we
report humoral and cellular immune responses from 20 Ad26.COV2.S vaccinated individuals …

Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters

LH Tostanoski, F Wegmann, AJ Martinot, C Loos… - Nature medicine, 2020 - nature.com
… In summary, our data demonstrate that a single immunization of Ad26-S.PP … -dose SARS-CoV-2
infection in hamsters. To our knowledge, vaccine protection against severe SARS-CoV-2 …

Ad26 vector-based COVID-19 vaccine encoding a prefusion-stabilized SARS-CoV-2 Spike immunogen induces potent humoral and cellular immune responses

R Bos, L Rutten, JEM van der Lubbe, MJG Bakkers… - npj Vaccines, 2020 - nature.com
… This optimized Ad26 vector-based vaccine for SARS-CoV-2, termed Ad26.COV2.… Ad26-based
vaccine candidates, or with 10 10 vp of an Ad26 vector without gene insert as control (Ad26

[HTML][HTML] Comparative analysis of ChAdOx1 nCoV-19 and Ad26. COV2. S SARS-CoV-2 vector vaccines

S Michalik, F Siegerist, R Palankar, K Franzke… - …, 2022 - ncbi.nlm.nih.gov
… The incidence rate of VITT/TTS seems to be higher for ChAdOx1 nCoV-19. … vaccinated with
Ad26.COV2.S, 3 compared to 1 per 50,000-100,000 people vaccinated with ChAdOx1 nCoV-…

Prior infection with SARS-CoV-2 boosts and broadens Ad26. COV2. S immunogenicity in a variant-dependent manner

R Keeton, SI Richardson, T Moyo-Gwete, T Hermanus… - Cell host & …, 2021 - cell.com
… Moreover, the South African arm of the trial showed similar levels of efficacy despite the
emergence of the neutralization-resistant SARS-CoV-2 Beta variant. Vaccination with Ad26.…

Comparative analysis of human immune responses following SARS-CoV-2 vaccination with BNT162b2, mRNA-1273, or Ad26. COV2. S

DJ Barbeau, JM Martin, E Carney, E Dougherty… - npj Vaccines, 2022 - nature.com
… post initial vaccination), following a second dose for both of the mRNA-based vaccines, the
… reported in immunogenicity studies of the various vaccines with Ad26.COV2.S achieving 2–3 …

Protective efficacy of Ad26. COV2. S against SARS-CoV-2 B. 1.351 in macaques

J Yu, LH Tostanoski, NB Mercado, K McMahan, J Liu… - Nature, 2021 - nature.com
… of virus in vaccinated macaques after B.1.351 challenge. These data demonstrate that
Ad26.… Our findings have important implications for vaccine control of SARS-CoV-2 variants of …

Low-dose Ad26. COV2. S protection against SARS-CoV-2 challenge in rhesus macaques

X He, A Chandrashekar, R Zahn, F Wegmann, J Yu… - Cell, 2021 - cell.com
immunization with an adenovirus serotype 26 (Ad26)-vector-based vaccine expressing
an optimized SARS-CoV-2 spike (Ad26.… S) protected rhesus macaques against SARS-CoV-2 …

Effectiveness of CoronaVac, ChAdOx1 nCoV-19, BNT162b2, and Ad26. COV2. S among individuals with previous SARS-CoV-2 infection in Brazil: a test-negative …

T Cerqueira-Silva, JR Andrews… - The Lancet Infectious …, 2022 - thelancet.com
… We did a test-negative, case-control study to evaluate the effectiveness of four vaccines (CoronaVac,
ChAdOx1 nCoV-19, Ad26.COV2.S, and BNT162b2) in individuals with previous …