… apoptosis is caspase-dependent and presumably through the mitochondrial pathway, as
shown by the activation of caspases-3, -9 and cleavage of poly(ADP-ribose) polymerase. …

… a selective caspase-9 inhibitor and 5-aminoisoquinolinone a selective Poly (ADP-ribose)
poly… Pretreatments with specific inhibitor of caspase-9, Ac-LEHD-cmk (0.07 µM and 0.105 µM), …

… pathway, mediated by poly(ADP-ribose) polymerase-1 (… of the nuclear enzyme poly(ADP-ribose)
polymerase-1 (PARP-1; EC … + and appears to be caspase independent. Several lines of …

… Caspase 9 is activated downstream of caspase 3 through the apoptosome [25]. Normal and
… positive for caspase 9 proenzyme (Fig. 2). However, activated caspase 9 was detected in …

… caspases 9 and 3 cascade is responsible for PARP-1 cleavage, the activities of initiator
caspase-9 and effector caspase-… AQ8 and AQ9 to maximally induce caspase-9 and -3 activities at …

… and endonuclease G, and leading to the activation of the apical caspase-9. Both pathways
converge on the cleavage of executioner caspases (3 and 7) to promote their activation [6]. …

… caspases (caspase-9) was analyzed in our samples. Procaspase-9 (not cleaved, inactive
caspase-9) … ), an effort was made to detect caspase-9 in our system; our data demonstrated that …

… of caspase-12, caspase9, caspase-8, and caspase-2. Using cellular fractionation and
immunofluorescence based studies we also demonstrate that caspase-… caspases in the cytoplasm. …

… are cleaved by caspases, most of them by the executioner caspase-3. However, caspase-7, …
sequence preference as caspase-3, is better at cleaving poly(ADP ribose) polymerase 1 (…

… PARP-1 −/− females had higher levels of mitochondrial cytochrome C, caspase-9, and
caspase-3 than WT mice suggesting that the caspase pathway is induced by the loss of PARP. …