… Herein, we present the 2.75 Å crystal structure of SARS-CoV-2 RBD in complex with the
Fab of CV30, assess the role of affinity maturation and determine in details its mechanism of …

… In the case of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), an
understanding of how viral variants evade antibodies and how affinity maturation could generate …

… -induced antibody affinity maturation and difference in antibody affinity between males
and … affinity may contribute to correlates of protection against SARS-CoV-2 and its variants. …

… to study the affinity maturation of CR3022 antibody in vitro, the findings provide useful
insights for the development of anti- SARS-CoV-2 antibody drugs for the treatment of COVID-19. …

… Our research not only provides a new method for antibody affinity maturation based on
computer modelling but also provides three high-affinity scFv fragments targeting the SARS-CoV-…

… As of September 2020, the numbers of SARS CoV-2 infected individuals in the world
surpassed 34 million and the rate of mortality is around 4–6% globally 1 . The disease …

… be consistent enough, SARS-CoV-2 is … affinity, which may escape future treatments. Thus
inspiring us to make precautionary therapeutics in the near future. 13 In silico affinity maturation …

… the related pandemic sarbecovirus, SARS-CoV-1 [25]. In this study, we have shown that the
affinity-matured decoy retains broad neutralizing activity against every SARS-CoV-2 variant …

… following SARS-CoV-2 infection or vaccination, their subsequent affinity maturation is of …
antibodies to develop broad cross-neutralization of SARS-CoV-2 through affinity maturation. …

… coronavirus 2 (SARS-CoV-2) Omicron variant now account for almost all SARS-CoV-2 …
affinity maturation in the development of cross-neutralization by a public class of antibodies. …