Antioxidant, Anti-Aging and Organ Protective Effects of Total Saponins from Aralia taibaiensis

H Li, B Zhai, J Sun, Y Fan, J Zou, J Cheng… - Drug Design …, 2021 - Taylor & Francis
… to have superior antioxidant effects to ginseng, schisandra and other saponins. Citation14,…
in aging rats through its antioxidant effect. Citation19 Further structure-effect relationship study …

[HTML][HTML] Regulatory effects of saponins from Panax japonicus on colonic epithelial tight junctions in aging rats

Y Dun, M Liu, J Chen, D Peng, H Zhao, Z Zhou… - Journal of Ginseng …, 2018 - Elsevier
… the protective effect of SPJ on intestinal barrier function in aging rats. Administration of SPJ …
and occludin in the colon of aging rats. The mechanism of the effects of SPJ might include the …

Saponins from Aralia taibaiensis Attenuate D‐Galactose‐Induced Aging in Rats by Activating FOXO3a and Nrf2 Pathways

YN Li, Y Guo, MM Xi, P Yang, XY Zhou… - Oxidative medicine …, 2014 - Wiley Online Library
… also confirming the protection of saponins. These results show … aging rat model is successful
and saponins from Aralia taibaiensis effectively attenuate D-galactose-induced aging in rats

Panax notoginseng saponins attenuate cardiomyocyte apoptosis through mitochondrial pathway in natural aging rats

Z Zhou, J Wang, Y Song, Y He, C Zhang… - Phytotherapy …, 2018 - Wiley Online Library
effect of PNS in aging heart. In the present study, we investigated the anti-apoptotic effect of
PNS in the aging rat … especially focusing on elucidating the effect of PNS in oxidative stress …

Saponins of Panax japonicus confer neuroprotection against brain aging through mitochondrial related oxidative stress and autophagy in rats

J Wan, R Wang, Z Zhou, L Deng… - Current …, 2020 - ingentaconnect.com
effects on D-galactoseinduced cognitive impairment in rats [17]. However, whether SPJ confer
neuroprotection in naturally aged ratseffects of SPJ on the naturally aged rat’s brain, and …

[HTML][HTML] Saponins of Panax japonicus ameliorates cardiac aging phenotype in aging rats by enhancing basal autophagy through AMPK/mTOR/ULK1 pathway

H Huang, T Wang, L Wang, Y Huang, W Li, Y Hu… - Experimental …, 2023 - Elsevier
… of aging rats To evaluate the potential of SPJ in improving cardiac function and structure in
aging rats, … The results showed systolic dysfunction in aging rats, manifested by a significant …

Saponins from Panax japonicus attenuate age-related neuroinflammation via regulation of the mitogen-activated protein kinase and nuclear factor kappa B signaling …

L Deng, D Yuan, Z Zhou, J Wan, C Zhang… - Neural regeneration …, 2017 - journals.lww.com
… SPJ inhibited the NF-κB signaling pathway in the cortex and hippocampus of aging rats
is involved in the anti-neuroinflammatory effect of SPJ on aging rats, we examined nuclear NF-…

Saponins from Panax japonicus improve neuronal mitochondrial injury of aging rats

C Fan, JX Wang, ZE Xiong, SS Hu, AJ Zhou… - Pharmaceutical …, 2023 - Taylor & Francis
… of mitochondrial dynamics in aging rats To further explore the effects of SPJ on the impaired
balance of mitochondrial dynamics in the hippocampus of aging rats, we determined the …

Improved effects of saponins from Panax japonicus on decline of cognitive function in natural aging rats via NLRP3 inflammasome pathway

B Ruan, R Wang, YJ Yang, DF Wang… - Zhongguo Zhong yao …, 2019 - europepmc.org
… The aim of this paper was to investigate the effect of total saponins from Panax japonicus(
SPJ) on cognitive decline of natural aging rats and its mechanism. Thirty male SD rats of …

Panax notoginseng saponins attenuate neuroinflammation through TXNIP-mediated NLRP3 inflammasome activation in aging rats

Z Zhou, M He, Q Zhao, D Wang… - Current …, 2021 - ingentaconnect.com
effects during aging [2]. Therefore, we detected whether PNS have an effect on the number
of microglia in the aging rat … increased in the aging group, whereas the aging group treated …