[HTML][HTML] The aging transcriptome and cellular landscape of the human lung in relation to SARS-CoV-2

RD Chow, M Majety, S Chen - Nature Communications, 2021 - nature.com
… landscape of the aging human lung in relation to SARS-CoV-2. We find that the aging lung
is … Through deconvolution analysis, we identify numerous age-associated alterations in the …

[HTML][HTML] Aging-related changes in the gene expression profile of human lungs

I Jeong, JH Lim, JS Park, YM Oh - Aging (Albany NY), 2020 - ncbi.nlm.nih.gov
… -seq transcriptome analysis of the lung tissues of 68 subjects and analyzed their gene expression
profile to evaluate candidate genes related to lung aging. … in relation to the level of lung

[HTML][HTML] Transcriptomics in lung tissue upon respiratory syncytial virus infection reveals aging as important modulator of immune activation and matrix maintenance

JLA Pennings, R Mariman, HM Hodemaekers… - Scientific reports, 2018 - nature.com
… in the lungs by aging. We therefore profiled the full transcriptome of lung tissue of mice
prior to and during RSV infection both at young and old age. In the absence of RSV, we found …

[HTML][HTML] Molecular programs of fibrotic change in aging human lung

S Lee, MN Islam, K Boostanpour, D Aran, G Jin… - Nature …, 2021 - nature.com
… published single-cell transcriptomes for three young, healthy human lungs 38 . Differential
… The linear structure–function relationship we report reveals a previously unknown inhibitory …

[HTML][HTML] An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics

I Angelidis, LM Simon, IE Fernandez, M Strunz… - Nature …, 2019 - nature.com
lungs 13 , serving as a starting point for investigating the lung in distinct biological conditions
as shown for lung aging in … -cell signatures of aging with state-of-the-art whole lung RNA-…

[HTML][HTML] The human blood transcriptome in a large population cohort and its relation to aging and health

M Schmidt, L Hopp, A Arakelyan, H Kirsten… - Frontiers in big …, 2020 - frontiersin.org
… two major blood transcriptome types where type 1 was found more in men, the elderly, and
… We find a striking overlap of signatures shared by multiple diseases, aging, and obesity …

[HTML][HTML] Transcriptomic profile of the mice aging lung is associated with inflammation and apoptosis as important pathways

J Calyeca, YI Balderas-Martínez, M Selman… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
lung transcriptome changes during aging, through a global gene expression analysis of normal
lungs of mice aged 4- … data on the relationship between chronic inflammation and cancer …

Transcriptomic analysis of human lung development

AT Kho, S Bhattacharya, KG Tantisira… - … journal of respiratory …, 2010 - atsjournals.org
… We predicted the age of independent human lung transcriptome profiles with a median …
by PCA), demonstrating the relationship between samples and ages. When the developing …

Similarities in Gene Expression Profiles during In Vitro Aging of Primary Human Embryonic Lung and Foreskin Fibroblasts

S Marthandan, S Priebe, M Baumgart… - BioMed research …, 2015 - Wiley Online Library
… the transcriptome, determined by RNA-seq, at five separate population doublings (PDs)
between young and senescent embryonic lung (… the variance and the relationship of global gene …

Age-associated differences in the human lung extracellular matrix

MLK Ngassie, M De Vries, T Borghuis… - … of Physiology-Lung …, 2023 - journals.physiology.org
… sections from the same lung in relation to chronic lung disease (ie, COPD and IPF) and …
The clinical characteristics of the control patients included in the transcriptomics data set are …