… the pathogenesis of Alzheimer'sdisease (AD), and this peptide is cut out of the amyloid β-protein precursor (APP) by the sequential action of β- and γ-secretases. γ-Secretase is a …
CJ Crump, DS Johnson, YM Li - Biochemistry, 2013 - ACS Publications
… of disease-modifying agents that target γ-secretase activity to lower levels of Aβ42 production without blocking the overall processing of γ-secretase substrates. γ-Secretase modulators (…
… the discovery of the γ-secretase components, the biological functions of γ-secretase, as well … , the role of γ-secretase in disease (especially in AD), and the current status and direction of …
SS Sisodia, PH St George-Hyslop - Nature Reviews Neuroscience, 2002 - nature.com
Investigations into the proteolytic processing of amyloid precursor protein (APP) have provided insights into both the pathogenesis of Alzheimer'sdisease and an unusual form of …
S Zhou, H Zhou, PJ Walian, BK Jap - Biochemistry, 2007 - ACS Publications
… γ-secretase complex is therefore believed to be critical in the pathogenesis of Alzheimer's disease… degree of γ-secretase complex activity; these include γ-secretase complex assembly …
DB Henley, PC May, RA Dean… - Expert opinion on …, 2009 - Taylor & Francis
… ), followed by a second cleavage by γ-secretase. γSecretase is a multimeric enzyme complex … The cleavage by γ-secretase at several sites results in Aβ peptides of various lengths, with …
MZ Kounnas, AM Danks, S Cheng, C Tyree… - Neuron, 2010 - cell.com
Alzheimer'sdisease (AD) is characterized pathologically by the abundance of senile plaques and neurofibrillary tangles in the brain. We synthesized over 1200 novel gamma-secretase …
L Serneels, J Van Biervliet, K Craessaerts, T Dejaegere… - Science, 2009 - science.org
… Intramembrane proteolysis by the γ-secretase complex is important during development and in the pathology of Alzheimer'sdisease. γ-Secretase has usually been considered as a …
G He, W Luo, P Li, C Remmers, WJ Netzer, J Hendrick… - Nature, 2010 - nature.com
… other γ-secretase substrates, especially Notch, which is essential for normal biological functions 3 , 4 . Here we report the discovery of a novel γ-secretase … with both γ-secretase and its …