… axonal transport (AT) defects play an important role in the pathogenesis of Alzheimer’ disease
… through different signaling pathways to cause AT defects. Mitochondrial transport, which is …

… Although we favor a mechanism in which defective axonal transport or age-related defects
in axonal transport precipitate AD, we recognize that this hypothesis does not account for all …

… alterations in phosphotransferases to axonal transport defects, axonal degeneration, and …
and axonal dysfunction in the pathogenesis of numerous neurodegenerative diseases …

… , but possibly also for Alzheimer's disease (AD) and related … mice with altered levels of
Alzheimer‐associated genes, … as tau, APP and PS, perturb axonal transport early on in AD, …

… that preceded known disease-related pathology by more than a year; we observed similar
axonal defects in the early stages of Alzheimer's disease in humans. Axonal defects consisted …

… in Alzheimer’s disease are unknown. Here we identify amyloid-plaque-associated axonal …
that a mouse model of Alzheimer’s disease demonstrates severe disruption in long-range …

… We note that axonal transport defects are seen in familial forms of frontotemporal dementia
with parkinsonism linked to chromosome 17, as well as other tauopathies, which are caused …

… of axonal transport with specific emphasis on the possible relationship between defective
axonal … In this review, we aim to summarize the current knowledge on axonal transport and …

… including defect of ATP … the defective ATP production will attenuate the axonal transport
undoubtedly, which is critical for neuronal survival (Chen and Chan, 2009). The defective axonal …

… -targeting NMDA receptor subunit NR2B, can enter the axon (20). Thus, selective filtering at
the … AnkG-defective AIS filtering mechanism as a critical determinant of axonal and neuronal …