… changes that lead to barrier leakage in patients and highlight the clinical relevance of
barrier leakage in AD. Third, we summarize signaling mechanisms that link barrier leakage to …

… leakage of the plasma protein prothrombin across the blood–brain barrier (BBB) in Alzheimer's
disease … Factor VIII staining in severe AD patients indicated that prothrombin leakage was …

… oncology due to relatively strong leakage of gadolinium contrast agent in high-… diseases in
whom the leakage is expected to be much lower (9–12). To investigate whether BBB leakage …

… Brain microvascular endothelial cells are the first barrier between blood vessels and brain
… BBB/NVU dysfunction has several pathological aspects, including: (1) the leakage of …

… impairment, dementia and Alzheimer’s disease (AD). Recent … Leaks in a protective filter
called the BBB are found in AD and other dementias 3 . Whether or not they contribute to disease …

The intactness of blood–brain barrier (BBB) is compromised in Alzheimer’s disease (AD).
Importantly, evidence suggests that the perturbation and abnormalities appearing in BBB can …

Brain capillary endothelial cells form the blood-brain barrier (BBB), which is covered with …
the pathogenesis of several neurological diseases, including Alzheimer’s disease (AD). While …

Alzheimer's disease (AD) is a complex illness characterized pathologically by accumulation
of protein aggregates of amyloid and tau in the brain (1). While most studies of AD focus on …

… We also discuss how BBB disruption can cause or contribute to Alzheimer’s disease (AD), …
is sealed to sufficiently prevent paracellular leakage under normal physiological conditions. …

The blood–brain barrier (BBB) plays critical roles in the maintenance of central nervous …
Dysfunction of the BBB occurs in a number of CNS diseases, including Alzheimer's disease (AD)…