… Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by the …
brain inflammation, which promotes disease pathogenesis. In this context, the blood-brain barrier …

… The blood–brain barrier (BBB) is formed by a tightly sealed monolayer of brain endothelial
cells, which keeps neurotoxic plasma-derived components, RBCs, leukocytes, and pathogens …

… Moreover, due to the loss of the protective function of the blood-brain barrier (BBB), impaired
… of the brain comprises the blood-brain barrier (BBB), which is a protective barrier that …

… In this review, we will discuss the participation of the blood–brain barrier (BBB) in AD with
special focus on its potential roles both upstream and downstream of the amyloid cascade. …

Brain capillary endothelial cells form the blood-brain barrier (BBB), which is covered with
basement membranes and is also surrounded by pericytes and astrocyte end-feet in the …

… in the context of health and disease. Herein, we provide a review on how the brain
barriers change during aging and in AD and how these processes impact on brain function. …

… brain barriers in safeguarding and maintaining brain health microenvironment. Generally,
three types of brain barriers … at three key interfaces between blood and brain tissue. The three …

… cognitive decline and dementia in Alzheimer’s disease (AD), … brain accumulation of the
Alzheimer’s neurotoxin, amyloid β-peptide (Aβ). The blood-brain barrier (BBB) is critical for brain …

… Alzheimer's disease (AD) drug development is limited by the presence of the blood-brain
barrier (BBB). More than 98% of all small-molecule drugs, and ∼100% of all large-molecule …

… is relevant to Alzheimer's disease with examples. Endothelial cell #1: Dysfunctions of BBB
can promote AD as exemplified here by impaired efflux of A-beta from brain. Endothelial cell #…