Alzheimer's disease: the cholesterol connection

L Puglielli, RE Tanzi, DM Kovacs - Nature neuroscience, 2003 - nature.com
… strongly support the involvement of cholesterol in both the generation and deposition of Aβ.
cholesterol diet also increased the deposition of amyloid plaques. Additionally, cholesterol-…

Cholesterol in Alzheimer's disease

LA Shobab, GYR Hsiung, HH Feldman - The Lancet Neurology, 2005 - thelancet.com
… has been associated with increased formation and deposition of amyloid-β peptide from …
of brain cholesterol in patients with Alzheimer's disease: abnormal induction of the cholesterol-…

Cholesterol in Alzheimer's disease and tauopathy

M Burns, K Duff - Annals of the New York Academy of Sciences, 2002 - Wiley Online Library
… that high cholesterol diet resulted in increased deposition of … As cholesterol plays such a
significant role in heart disease … available that target cholesterol biosynthesis. Studies on PS/…

Cholesterol and pathological processes in Alzheimer's disease

K Yanagisawa - Journal of neuroscience research, 2002 - Wiley Online Library
… The relationship between the degree of deposition of Aβ or formation of neuritic plaques
in human brains and the serum cholesterol level has recently been investigated. Kuo et al. (1998…

Cholesterol in Alzheimer's disease: unresolved questions

M Stefani, G Liguri - Current Alzheimer Research, 2009 - ingentaconnect.com
… as main cholesterol carrier in the brain also underlie a close cholesterol load-AD risk relation.
Finally, cell biology evidences support a critical involvement of lipid raft cholesterol in the …

Cholesterol metabolism and transport in the pathogenesis of Alzheimer's disease

IJ Martins, T Berger, MJ Sharman… - Journal of …, 2009 - Wiley Online Library
… from the circulation may contribute to amyloid deposition. Increased oxysterol concentrations
may protect neural tissues by attenuating further Aβ deposition and by activation of the liver …

The link between cholesterol and Alzheimer's disease

M Sjögren, K Blennow - The World Journal of Biological Psychiatry, 2005 - Taylor & Francis
… on the link between cholesterol and Alzheimer’s disease. Key words: Cholesterol, statins,
b-… Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a …

[HTML][HTML] Role of LDL cholesterol and endolysosomes in amyloidogenesis and Alzheimer's disease

X Chen, L Hui, JD Geiger - Journal of neurology & …, 2014 - ncbi.nlm.nih.gov
… The pathogenesis of late-onset sporadic Alzheimer's disease (AD) is … Among those factors,
altered circulating cholesterol … Although cholesterol-induced brain deposition of Aβ might …

Link between heart disease, cholesterol, and Alzheimer's disease: a review

DL Sparks, TA Martin, DR Gross… - Microscopy research …, 2000 - Wiley Online Library
… Increased prevalence of Alzheimer’s disease-like β-amyloid deposits in the neuropil and …
individuals with heart disease. Heart disease is a prevalent finding in Alzheimer’s disease, and …

Cholesterol and Alzheimer's disease—is there a relation?

M Sjögren, M Mielke, D Gustafson, P Zandi… - Mechanisms of ageing …, 2006 - Elsevier
… on the pathophysiology of Alzheimer's disease (AD) concerns … in the endogenous synthesis
of cholesterol but also affect enzymes … on cholesterol and Alzheimer's disease are presented. …